Bing Pian

Borneolum, Borneol

Dosage

Internal administration: 0.15 to 0.3g, in pill or powder form. Do not used in decoction form. External use: Appropriate doses ground into powder for topical application or making into paste then applied.

Toxicity

LD50 of bornyl, isobornyl, and borneol syntheticum by oral administration is 2879, 2269, and 2507mg/kg.

Chemical Composition

D-bornyl; Isobornyl; b-elemene; Caryophyllene; Triterpenoids; Asoleamolic acid; Maizhuzi acid; Asiatic acid; Boryl hydrinone; Boryl hydrindiolone; Cineole; L-borneol; Sesquiterterpenol; Isoborneol. (1) , (2) , (3) , (4)

Inorganic Chemicals

It also contains traces of the element Pb.

Precautions

Pregnant women and those deficient in qi and blood should use with caution. An allergic reaction to Bing Pian has been reported in oral and external administrations. (5) , (6) , (7) , (8)

Pharmacology

Anti-fertility effects

Intra-peritoneal injections of Bing Pian at doses of 1/4, 1/8, and 1/16 of LD50 were administered to mice at different stages in pregnancy. It distinctly induced abortion in intermediate and advanced stages of pregnancy in mice. It has no significant effect in the early stages of pregnancy. (9)

Increase the permeability of blood-brain barrier

Liang Mei Rong observed the effects of Bing Pian on the blood-brain barrier by examining the intensity of coloration in the brain tissue after administering Evan’s Blue. It was found that Bing Pian pills could increase the intensity of the blue stained brain tissue in rabbits and rats. This suggests that Bing Pian may increase the permeability of the blood-brain barrier. (10) It was found that the gentamicin concentration in brain tissue increased after administering Bing Pian to rats. (11) It was demonstrated by Xu Wei that the half-life of sulfadiazine in rats was largely prolonged after gastrolavage of Bing Pian (10% Bing Pian in paraffin oil 15ml/kg), and the sulfadiazine concentrations in the rat brain tissue increased. (12)

Anti-inflammation and analgesia

Footpad swelling in mice, induced by egg albumin was markedly suppressed by borneal and isoborneal. Isoborneal was also effective in reducing cedar-oil generated swelling in mouse ear lobes. (13) In guinea pigs, Bing Pian acted as strong anti-inflammatory and analgesic agents for burns caused by a laser. (14)

Promoting membrane permeability of corneal epithelium

Experiments showed that Bing Pian promoted permeability in the corneal epithelium of rabbits. Cultured corneal epithelial cells were divided into two comparison groups and one experimental group. Sequence parameters arrangements of membrane phospholipid molecules in both groups were examined using the electron spinning resonance method. The sequence parameters of the two control groups and the experimental group were 0.711±0.024, 0.717±0.018, and 0.743±0.039, respectively. The differences between the experimental group and the two control groups were significant (P

Anti-microbial effect

Zhao Xiao Yang studied the effects of Bing Pian on eight types of mycosis. It was shown that Bing Pian is relatively potent against microsporum, Hormodendrum pedrosoi, and sporotrichum. It could suppress the growth of corynebactrium minutissimum at a 5% concentration and sporocytic at a 10% concentration. It suppressed the growth of aspergillus by 10%. (15) Clinical studies showed that the minimal inhibitory concentration was 5% to inhibit Aspergillus Niger isolated from the exudate of the external auditory canal and other mycosis. The minimal anti-fungal concentration of Bing Pian was 10%. The changes in ultramicroscopic cellular structures were studied using electron microscopy. It was shown that Bing Pian damaged the cellular structure of mycosis, resulting in lysis and death of the mycosis, thereby showing the antimycotic and sporicidal effects of borneol. (16)

References

  1. Long Xin Hua, et al. Research on quality standards of natural Bing Pian produced in China. Journal of Traditional Chinese Medicine Material. 2000;23(7):394-395.
  2. Dictionary of Chinese Medicines. Edited by Jiangsu New Medical College. Shanghai Science and Technology Press, 1986.
  3. Wan Xiao Xia. Research advances on Bing Pian pharmacology. Journal of Guangdong College Pharmacy. 1997;13(2):115-117.
  4. Zhang Zhen Kang. Using spectrophotometry to determine lead content in E Jiao and Bing Pian. Journal of Shizhen Medicine. 1999;10(3):1-2.
  5. Zhang Shu Wen, et al. Initiation of one case of contact dermatitis by Bing Pian’s external administration. Journal of External Application of TCM. 1996;5(2):22.
  6. Liang Li Ping. Report of one case of Bing Pian induced allergic reaction. China Journal of Chinese Medicine. 1989;14(3):182-183.
  7. Zhong Zhuan Zhen. Report of two cases of Bing Pian induced allergic dermatitis. Journal of Yunnan College of TCM. 1990;13(2):38.
  8. Xiang De Dong. Report of one case of drug rash by bathing with Bing Pian. Journal of External Application of TCM. 1998;7(1):46.
  9. Xu Lian Ying, et al. Research on Bing Pian’s obstetrical effects and dosage. Journal of Chinese Patented Medicine Research. 1986;(3):1-2.
  10. Liang Mei Rong, et al. Observation on Bing Pian’s Evan’s blue staining effects via brain tissue of rabitt or rat. Journal of Guangzhou College of TCM. 1993;10(4):211-213.
  11. Liu Qi De, et al. Bing Pian’s effects on gentamycin’s permeating blood-brain barrier. Journal of Guangzhou College of TCM. 1994;11(1):37-40.
  12. Xu Wei, et al. Bing Pian’s effects on distribution of sulfamidiazine and Evan’s Blue in brain. Journal of Pharmacology and Clinical Application of TCM. 1995;11(6):31-33.
  13. Jiang Guang Chi, et al. Borneal and isoborneal’s pharmacology effects on mice and rabbits. Journal of Chinese and Western Pharmacy. 1989;4(1):23.
  14. Huo Gui Zhi, et al. Bing Pian’s anti-inflammation and analgesia effects on laser burn wounds. China Journal of Pharmacy. 1995;30(9):532-534.
  15. Zhao Xiao Yang, et al. Ultrastrcuture observation on Bing Pian’s antimicrobial effect. Journal of Haerbin Univesity of Medicine. 1992;26(3):295.
  16. Chang Song Ping, et al. Bing Pian’s effects on ultrastructure of fungal cell and clinical application of treating otitis media supurativa. China Journal of Chinese Medicine. 2000;25(5):306-308.