Bai Bian Dou

Semen Lablab Album, Dolichos

Dosage

Oral administration: 5 to 10g for decoction, pill, or powder form.
External use: it Powdered or applied after mixing with liquid.
5:1 concentrated extracts: 1 to 2g.

Toxicity

Phytoagglutinin A is not water-soluble. When mixed with forage for rats, it can inhibit their growth, and even induce regional necrosis of the liver. Heating can significantly reduce the toxicity levels. (1)

Chemical Composition

Linoleic acid; Elaidic acid; Stearic acid; Behenic acid; Palmitic acid; Oleic acid; Arachidic acid; Rigonelline; Methionine; Leucine; Threonine; Vitamin B1 and C; Carotene; Sucrose; Glucose; Stachyose; Maltose; Raffinose; L-2-pipecolic acid; Phytoagglutinin; Phytin; Pantothenic acid; Luteolin; Cosmosiin; Luteolin-4'-0-D-glucopyranoside; Luteolin-7-0-D-glucopyranoside; Rhoifolin; D-mannitol. (2) , (3) , (4)

Inorganic Chemicals

It also contains the elements Ca, P, Fe, and Zn.

Precautions

It is contraindicated for patients with qi deficiency without stasis, or yin deficiency with blood heat. It has been reported that Bai Bian Dou can induce poisoning when it is not well cooked. (5)

Pharmacology

Effects on immune functions

20% of a Bai Bian Dou cold saline extract (0.3ml) could promote the formation of active E-rosettes. This activity could mean that Bai Bian Dou could enhance T-lymphocytes and promote cellular immune functions. (6) Studies also indicate that Bai Bian Dou can promote the recovery of weakened immune functions. (7)

Increasing leukocytes

Bai Bian Dou can restore the reduction the amount of mouse total leukocytes induced by cyclophosphamide to the normal level. (8)

Antibacterial and antiviral effects

1g/ml of a Bai Bian Dou decoction can inhibit Bacillus dysenteriae as well as show detoxifying effects on vomiting and acute gastroenteritis induced by food poisoning. (9) In addition, this decoction of the seed had inhibiting effects on the Columbia SK virus in mice. (10)

Inhibiting blood coagulation

Contained in the seed, non-specific lectin has certain characters of globulin. It is water-soluble and inhibits thrombase. When in the concentration of 10mg/ml, it could postpone the blood clotting time from 20 minutes to 60 minutes. When isolated and purified from the herb, studies have shown that DLA, which is extracted from Bai Bian Dou, has similar effects as ConA. It has strong coagulation effects on red blood cells, independent of specific blood types. (11)

References

  1. Modern TCM Pharmacology. Tianjin Science and Technology Press, 1997.
  2. Chinese Materia Medica. Shanghai Science and Technology Press, 1998.
  3. Modern TCM Pharmacology. Tianjin Science and Technology Press, 1997.
  4. Liang Qiao Li, et al. Research on Bian Dou Hua chemical composition. Journal of University of Pharmacology of China. 1996;27(4):205-207.
  5. Li Xing Feng, et al. Analysis of one case of uncooked Bian Dou. Journal of Shizhen Medicine. 1999;10(10):771.
  6. Ma Zheng Ya, et al. Experimental observation on cellular immune function effects of bean related Chinese Herbs. Shannxi Journal of Traditional Chinese Medicine and Herbs. 1979;8(5):54-57.
  7. Zhao Lian Ken, et al. Comparison and research on organism defense function effects of various tonic herbs. Journal of Chinese Materia Medica. 1990;31(4):52-53.
  8. Zhao Lian Ken, et al. Comparison and research on organism defense function effects of various tonic herbs. Journal of Chinese Materia Medica. 1990;31(4):52-53.
  9. Dictionary of Chinese Medicines. Shanghai Science and Technology Press, 1986:1742.
  10. Zheng Jao Long. Pharmacology research and clinical application of Bian Dou. Journal of Shizhen Medicine. 1997;8(4):330-331.
  11. Modern TCM Pharmacology. Tianjin Science and Technology Press, 1997.