Study of The Different Sample Preparation Methods for The Detection of Heavy Metals in Locally Avail

Author

Helal Uddin A.B.M., Siiti Nurfairuz M.F., Mohamad Shahreen A., Saeed M.   Department of Pharmaceutical Chemistry, Kulliyah of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Istana, Bandar Indera Mahkota, 25200 Kuantan, Pahang. Mohd Asri M.N. School of Chemical Sciences, Universiti Sains Malaysia (USM), 11800 Minden, Penang. Email: This email address is being protected from spambots. You need JavaScript enabled to view it.; This email address is being protected from spambots. You need JavaScript enabled to view it.

Language

English

Title

Study of The Different Sample Preparation Methods for The Detection of Heavy Metals in Locally Available Traditional Medicines

Proceeding

Medicinal and Aromatic Plants Seminar (MAPS 2008)

Date

21st October - 22nd October 2008

Place Held

The Legend Hotel, Kuala Lumpur

Abstract

Traditional medicines have been globally used for many years for prevention and treatment of diseases. However, problems and difficulties arise in the quality assurance of traditional medicinal products because there are so many unidentified chemical entities in the finished products together with the actual active components. Heavy metal toxicity in traditional medicine is very common and often causes serious problems to patients. Malysian Drug Control Authority has made it compulsary for traditional medicines to be registered. Limit of the heavy metals is one of the major criteria for the registration of the products. The present study showed the comparision of different sample preparation methods for the metal ion detection in selected traditional medicines using flame atomic absorption spectroscopy technique (FAAS). Hollow cathode lamp was used as a radiation source and air acetylene mixture was used for the flame. The wavelength for lead and cadmium were 283.3 and 228.8, respectively. Sample preparation steps involved acid digestion of the sample using two different digestion methods, namely, nitric acid-hydrochloric acid and nitric acid-perchloric acid digestion. Twenty-three traditional medicine samples, commonly used to treat various illnessess were analysed for the presence of lead and cadmium. Of the two digestion processess, nitric-perchloric acid digestion process showed better results than that of nitric acid-hydrochloric acid digestion. Four of the samples showed absence of lead and six of them showed absence of cadmium in both digestion systems.

Keywords

FAAS; traditional medicine; acid digestion; heavy metals; lead; cadmium

Session

Poster Abstracts

Topic

Think Global, Act Local: A New Paradigm In Malaysian Herbal Industry (Prof. Emeritus Dr. Abdul Latif Ibrahim-UNISEL)