Cyclea laxiflora

Synonyms

Not documentation

Vernacular Names:

Malaysia

Akar Gasing Bukit, Terong Kermau (Langkawi); Kong Kermo (Nerang Kedah); Selenban Beri (Semelai); Akar Rempenang, Metimun Tikus

Indonesia

Akar Pahit [1] [3] [4] [5] [7]

General Information

Description

Cyclea laxiflora is a member of the Menispermaceae family. It is slender herbaceous or slightly woody, hairy climber. The stem is hispid or glabrous. The leaves are peltate ovate or heart-shaped 8-15cm long; hairy below with petiole measuring up to 6cm long and usually hispid. The male flowers has glabrous or subglabrous calyx and free petals while the female flowers are in lax clusters with glabrous or subglabrous carpels. The fruit are glabrous. [1] [7]

Plant Part Used

Roots [7]

Chemical Constituents

(+)-dicentrine [2]

Traditional Used:

Respiratory Diseases

The tuberous roots of C. laxiflora is a remedy for caries of nasal bone. A condition known as “resdong” in Malay and believed to be syphilitic in origin. [7] In Indonesia it is reported to be used for asthma. [4]

Other uses

In Nerang, Kedah the roots is used to treat headache. [4] The Semelai of Pahang use the tuber either raw or boiled to treat kidney problems and constipation. [5] The decoction of the root is a local medicine for fever, piles and worm infestation in other parts of Peninsula Malaysia. [7] This decoction is also given to women after delivery. [7]

Pre-Clinical Data

Pharmacology


No documentation

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

  1. Hsuan Keng The Concise Flora of Singapore – Gymnosperms and Dicotyledons Singapore University Press Singapore 1990 pg. 21
  2. S. W. Pelletier Alkaloïds: chemical and biological perspectives, Volume 14 Elservier Science Ltd. Oxford 1999 pg. 413
  3. Batugal, P.A., Kanniah, J., Sy, L., Oliver, J.T. (eds.) Medicinal Plants Research in Asia - Volume I: The Framework and Project Workplans IPGRI-APO Serdang 2004 pg. 122
  4. Alan M. Stevens Kamus Lengkap Indonesia Inggris PT Mizan Pusaka Bandung 2008  pg 17
  5. Field Guide to Plants of Tasek Bera (http://www.ruffordsmallgrants.org/files/Field%20Guide_0.pdf) Accessed on 02nd October 2010
  6. Kondo Y, Imai Y, Hojo H, Endo T, Nozoe S. Suppression of tumor cell growth and mitogen response by aporphine alkaloids, dicentrine, glaucine, corydine, and apomorphine. J Pharmacobiodyn. 1990 Jul;13(7):426-31.
  7. E-Prosea Detail. (http://www.proseanet.org/prosea/e-prosea_detail.php?frt=&id=119) [Accessed on 29th October 2010]