Ardisia crenata

Synonyms

No documentation

Vernacular Names:

Malaysia

Mata Ayam, Mata Itek

English

Coral Berry, Christmas Berry, Hilo Holly, Marlberry, Ardisia

China

Yun Chi Zi Jin Niu

Hong Kong

Chu Sar Gun

Korea

Baek-ryang-geum

Japanese

Manryo [1]

General Information

Description

Ardisia crenata is a member of the Myrsinaceae family. It is a small, slow-growing, evergreen shrub reaching up to 1.8m in height, growing in muti-stemmed clumps. The leaves are alternate, oblong-lanceolate, up to 20cm long, with crenate and undulate margins, glossy dark green above, waxy and glabrous. The flowers are white to pink in colour with stalked axillary clusters, small in nodding corymbs. The fruits are globose in shape, one-seeded drope up to 8 mm in diameter and glossy red when ripe.[12]

Plant Part Used

Roots, leaves and fruits [1]

Chemical Constituents

11-O-syringylbergenin; ardicrenin; ardicretin; ardisiacrispins A and B; ardisicrenosides A – L; bergenin; beta-sitosterol-beta-D-glucoside; beta-sitosterol; carotene; cyclic depsipeptide; cyclamiretin A; dimethyl-bergenin; friedelin; norbergenin; rapanone; spinasterol; sucrose [1][2][3][4][5][6][7]

Traditional Used:

In China and Hong Kong it is used in the treatment or rheumatic arthritis, traumatic injuries, lumbago, fractures, swelling of wounds and snake bites. It is believed to have antibacterial properties and is used in the treatment of tonsillitis, bronchitis, lymphadenitis, upper respiratory tract infections, diphtheria, erysipelas and scarlet fever. [1]

In Malaysia the decoction of the roots is given to women after delivery, for fever, cough and gout. Poultice of leaves and roots are applied over areas of bone-aches.

Pre-Clinical Data

Pharmacology

Antithrombin activity

In a chromogenic bioassay of 30 plants to determine their antithrombin activity, Studies [11] reported that the extracts of A. crenata were amongst those with antithrombin activity of 80% or higher.

Antimicrobial activity

Antifunga activity

The triterpenoid saponins ardicrenoside K and L compounds reported weak antifungal activity against the plant pathogenic fungus Pyricularia oryzae.[7]

Cytotoxic activity

Ardisiacrispin A and B compound in a mixture was a subject for anticancer activity study on human cancer cells. Its underlying mechanism of action was also determined. Of the several human cancer cell lines tested it was found that Bel-7402 was the most sensitive to this compound. Ardisiacrispin could induce apoptosis in a dose-dependent manner with changes in mitochondrial depolarization, membrane permeability enhancement and nuclear condensation being observed. It could also disassemble microtubules.[9]

Ardisiacrenoside I compound also reported cytotoxic activity in several human tumour cell lines.[10] Recently, studies[11] reported that A. crenata was amongst the six Ardisia sp. to have anticancer potentials against liver cancer cells in vitro.

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

A. crenata use with anticoagulant therapy should be carefully evaluated because of the proven antithrombin activity the plant possesses. [11]

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

    1. Takeatsu Kimura International Collation of Traditional and Folk Medicine Volume 3 World Scientific Publicshing Co. Pte. Ltd. Singapore 1998 pg 519
    2. Han L, Ni MY. [Studies on the chemical constituents of Ardisia crenata Sims] Zhongguo Zhong Yao Za Zhi. 1989 Dec;14(12):737-9, 762-3.
    3. Maotian W, Xiongtai G, Xiuwen H, Shanhai H. A new triterpenoid saponin from Ardisia crenata. Planta Med. 1992 Apr;58(2):205-7.
    4. Jia Z, Koike K, Ohmoto T, Ni M. Triterpenoid saponins from Ardisia crenata. Phytochemistry. 1994 Nov;37(5):1389-96.
    5. Jia Z, Koike K, Nikaido T, Ohmoto T, Ni M. Triterpenoid saponins from Ardisia crenata and their inhibitory activity on cAMP phosphodiesterase. Chem Pharm Bull (Tokyo). 1994 Nov;42(11):2309-14.
    6. Koike K, Jia Z, Ohura S, Mochida S, Nikaido T. Minor triterpenoid saponins from Ardisia crenata. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):434-5.
    7. Liu DL, Wang NL, Zhang X, Gao H, Yao XS. Two new triterpenoid saponins from Ardisia crenata. J Asian Nat Prod Res. 2007 Mar;9(2):119-27.
    8. Li M, Wei SY, Xu B, Guo W, Liu DL, Cui JR, Yao XS. Pro-apoptotic and microtubule-disassembly effects of ardisiacrispin (A+B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel-7402 cells. J Asian Nat Prod Res. 2008 Jul-Aug;10(7-8):739-46.
    9. Zheng ZF, Xu JF, Feng ZM, Zhang PC. Cytotoxic triterpenoid saponins from the roots of Ardisia crenata. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):833-9.
    10. Newell AM, Yousef GG, Lila MA, Ramírez-Mares MV, de Mejia EG. Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells. J Ethnopharmacol. 2010 Aug 9;130(3):536-44. Epub 2010 Jun 2.
    11. Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Howard Miles D. Antithrombin activity of medicinal plants from central Florida. J Ethnopharmacol. 2002 Jul;81(2):277-80.
    12. Florida Exotic Pest Plant Council  http://www.fleppc.org/ID_book/ardisia%20crenata.pdf [Accessed 21st November 2010]