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Gynura pseudo-china

Synonyms

Cacalia bulbosa Loureiro, Gynura bodinieri H. Léveillé, Gynura bulbosa (Loureiro) Hooker & Arnott, Gynura miniata Welw, Senecio bulbosus (Loureiro) H. Léveillé , Senecio crassipes H. Léveillé & Vaniot, Senecio pseudochina Linn. [2] [3]

Vernacular Names:

Malaysia

Daun Dewa Merah

Indonesia

Daun Dewa Merah

Thailand

Waan Mahaakaan

China

Gou Tou Qi. [1] [2]

General Information

Description

Gynura pseudochina is a member of the Asteraceae family. It is a perennial herbaceous plant with erect, semi-succulent stem that can reach up to 130cm high. The roots are tuberous and they are round or lobed, measuring 2-6cm in diameter. The leaves form a rosette with the upper ones more dissected and smaller. They are simple, shallowly lobed with petiole measure ranging from 0.3-3cm long. The blade is obovate, spatulate, elliptical or ovate measuring 7-40cm x 5-20cm. The inflorescence is a campanulate head, loose, racemose or paniculate. The peduncle is 4cm long. The inner involucral bracts are measure 7-12mm long; corolla measure 10-13mm long, yellow to red in colour. The achene is measuring 3-4mm long. [2]

Plant Part Used

Tuber and leaves. [1]

Chemical Constituents

3,5-di-caffeoylquinic acid; 4,5-di-caffeoylquinic acid; 5-monocaffeoylquinic acid; quercetin 3- rutinoside. [4]

Traditional Used:

The tuber is considered antipyretic, haemostatic, anti-inflammatory and antiviral.

Inflammatory Diseases

The leaves in the form of a poultice is used to treat insect bites, pimples, bruises, haematoma, and erysipelas. The tuberous roots make excellent poultice for herpes simplex and herpes zoster. The plant is also used to treat fever. [1] [2] [6]

Gynaecological Diseases 

The leaves pounded in brine, is given as a remedy for dysfunctional uterine bleeding. The plant is also used to treat breast tumours in the form of local application of poultice. [1] [2] [6]

Other uses

In Eastern Nigeria the leaves which are mucilaginous are used in preparation of soups and sauces. The fresh leaves are used for their demulcent property, and the leaf sap is used to treat sore eyes. [2]

Pre-Clinical Data

Pharmacology

NK-kappa B inhibitory activity

A screening of 9 Thai medicinal plants to study their anti-inflammatory, anti-proliferative and antioxidant activities had shown that G. pseudochina var hispida has NF-kappaB inhibitory activity. In a bioassay-guided fractionation of the methanol extract lead to the isolation and characterization of four compounds (Quercetin 3- rutinoside; 3,5-di-caffeoylquinic acid; 4,5-di-caffeoylquinic acid; and 5-monocaffeoylquinic acid) believed to be responsible for this activity. [4] [5]

Toxicities

No documentation.

Teratogenic effects

No documentation.

Clinical Data

Clinical Trials

No documentation.

Adverse Effects in Human:

No documentation.

Used in Certain Conditions

Pregnancy / Breastfeeding

No documentation.

Age Limitations

Neonates / Adolescents

No documentation.

Geriatrics

No documentation.

Chronic Disease Conditions

No documentation.

Interactions

Interactions with drugs

No documentation.

Interactions with Other Herbs / Herbal Constituents

No documentation.

Contraindications

Contraindications

No documentation.

Case Reports

No documentation.

References

1. Dalimartha S. Atlas Tumbuhan Obat Indonesia Jilid 4, Puspa Swara. Jakarta. 2007. pg. 23 – 24 [http://books.google.com.my/books?id=-1TuYu_7ehoC&pg=PR6&lpg=PR6&dq=gynura+pseudochina+var+hispida&source=bl&ots=VYAFH8Ai6D&sig=_69FvS-bwxk6yenLV7ECuFvHgIw&hl=en&sa=X&ei=a8Q6UdiKKMmsrAe28YCYDA&redir_esc=y#v=onepage&q=gynura%20pseudochina%20var%20hispida&f=false]
2. Grubben GJH. Plant Resource of Tropical Africa Volume 2 – Vegetables, PROTA Foundation, Wageningen 2004 pg. 309 [http://books.google.com.my/books?id=6jrlyOPfr24C&pg=PA656&dq=gynura+pseudochina+var+hispida&hl=en&sa=X&ei=LMY6UaalOcXXrQfy8YC4Ag&redir_esc=y#v=onepage&q=gynura%20pseudochina%20var%20hispida&f=false]
3. Flora of China. Available from [http://www.efloras.org/florataxon.aspx?flora_id=2&taxon_id=242324268] Accessed 9th March 2013
4. Siriwatanametanon N, Heinrich M. The Thai medicinal plant Gynura pseudochina var. hispida: chemical composition and in vitro NF-kappaB inhibitory activity. Nat Prod Commun. 2011 May;6(5):627-30.
5. Siriwatanametanon N, Fiebich BL, Efferth T, Prieto JM, Heinrich M. Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities. J Ethnopharmacol. 2010 Jul 20;130(2):196-207.
6. Burkill IH. A Dictionary of the Economic Products of the Malay Peninsula, Volume 1, Ministry of Agriculture and Cooperatives Malaysia. Kuala Lumpur. 1966, pg. 1140.

 

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