Hepatoprotective Activity of Iranian Traditional Medicine Herb Extracts Against Acetaminophen-Induced Liver Injury in Mice.


O. Sabzevari, I. Emrarian and H. Kalantari


Traditional & Complementary Medicine Exhibition 2007 (TCME 2007), Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia




Hepatoprotection-Iranian-traditional herbs


The task of maintaining metabolic homeostasis, secretory and excretory functions facilitates in the body by the liver and, accordingly, its disorders are numerous and varied.Plantago psylliumand Fumaria plants have been used in traditional medicine as a remedy for some liver diseases. The present study evaluates the hepatoprotective potential of aqueous­methanolic extracts of these medicinal herbs against acetaminophen-induced acute liver injury and mortality rate, in comparison to a known hepatoprotective plant extract,Silybium marianum. Plant extracts at a dose of 500 or 1000 mg/kg BW were administered orally for 3 days (twice daily), one hour after acetaminophen administration at a single dose of 1 g/kg BW in mice. The liver injury was measured by determining the serum levels of glutamate-oxalate-transaminase and glutamate-pyruvate-transaminase (GOT and GPT). At the dose of 1 g/kg, acetaminophen caused 100% mortality in mice, while post­treatment of animals with six successive doses of (500 or 1000 mg/kg)Plantago psylliumextract reduced the mortality rate to 60% and with Fumaria extract to 80% and 60%, respectively. The mortality rate reductions withS. marianumextract were 40% and 20%, respectively. The herbal extracts at the employed doses, significantly lowered the acetaminophen-induced risein the serum levels of SGOT and SGPT. These results indicate that the crude extracts ofP. psylliumand Fumaria reduce the mortality rate of acute acetaminophen toxicity and exhibits hepatoprotective action against acetaminophen-induced liver injury which can be compared to that ofS. marianum. The findings further validate the traditional use of plants in hepatic damage.