Nematocidal Activity Of Tumeric : Synergistic Action Of Curcuminoids


Fumiyuki Kiuchi1, Yoshihisa Goto1, Naoki Sugimoto1, Nobuaki Akao2, Kaoru Kondo2, and Yoshisuke Tsuda1, 1Faculty of Pharmaceutical Sciences, and 2School of Medicine, Kanazawa University 13-1 Takara-machi, Kanazawa 920, Japan.


Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




Curcuma longa; Zingiberaceae; turmeric; nematocidal activity; synergistic effect; cyclocurcumin; curcuminoids.


A new curcuminoid, cyclocurcumin(IV), was isolated from the nematocidally active fraction of turmeric, the rhizome of Curcuma longa, together with three known curcuminoids, curcumin(I), demethoxycurcumtn(II) and bisdemethoxycurcumin(III). The structure of IV was elucidated on the basis of spectral data and confirmed fjy the partial synthesis from curcumin(I). Although the above curcuminoids were ineffective against the larva of dog roundworm, Toxocara canis, when they were applied independently, the nematocidal activity increased remarkably when they were mixed, suggesting a synergistic action between them.