The Effects Of New Compounds Isolated From Medical Herbs On Smooth Muscle Contractions


Rohaini Mohamad, M.M.Rais, Ranjit Kaur, D.Laily*, M.S.Wahid*, Department of Pharmacology, Faculty of Medicine, University of Malaya 59100 Kuala Lumpur and *Department of Chemistry, University Kebangsaan Malaysia, 43600 Bangi, Malaysia.


Trends in Traditional Medicine Research, Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care




herbs, new compounds, Smooth muscle relaxant, percent inhibition of noradrenaline induced contraction and KCl-induced contraction


In the rat vas deferens, of the seven new compounds isolated from medicinal plants, dicentrine , isocorydine and usnic acid inhibited both noradrenaline - induced contractions and KCl-induced contractions; probably by inhibiting intracellular Ca++ release to the contractile elements. Isocorydine and usnic acid but not dicentrine and techtochrysin may cause inhibition via mediation of cGMP. Atranorine, goniothalamin and isoaltholactone, on the other hand, enhanced the noradrenaline-induced contractions. In the rat uterus, usnic acid, techtochrysin and isocorydine were very potent inhibitor of the spontaneous contractions.