Anti- Inflammatory Of Myristica fragrans (Nutmeg) In Acute Inflammation


Saadiah Mohd Hadir and Lekhsan Othman


The Fifteenth Malaysian Biochemical Society In Conference : Focus on Biochemistry in Malaysia in the 1990's, Faculty Of Medicine Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia




anti- Inflammatory effect, Myristica fragrans (Nutmeg), acute Inflammation


The water extract of nutmeg when given intraperitoneally at a dose of lg/kg was shown to have strong anti-inflammatory effect on two models of acute inflammation in rats: the carrageenin-induced oedema and the serotonin-induced oedema. The aqueous extract was also shown to have irritant property. Irritants can exert anti-inflammatory effect through 'counter-irritant' mechanism. The results do not demonstrate that the ability of the aqueous extract to reduce inflammation is entirely due to its irritancy, and the possibility cannot be ruled out that the anti-inflammatory effect is due to both counter-irritancy and other mechanisms of action.