Contribution of the opioid system to realization of inotropic effects of Rhodiola rosea extracts in ischemic and reperfusion heart damage in vitro


Lishmanov IuB, Naumova AV, Afanas'ev SA




Eksp Klin Farmakol


It has been established that a course of oral administration of Rhodiola rosea extract in a dose of 3.5 mg/kg prevents reperfusion decrease in contraction amplitude of the isolated perfused rat heart. It also prevents reduction of coronary flow and development of contracture in the postischemic period. Intravenous infusion of naloxone (0.5 mg/kg) completely abolishes the favorable effect of Rhodiola in relation to the heart contractility and coronary flow parameters. The protective effect of Rhodiola may probably be connected with increase in the level of endogenous opioid peptides.