Chitosan decreases total cholesterol in women: a randomized, double-blind, palcebo-controlled trail.


Bokura H, et al.






Background: Hypercholesterolemia is an important risk factor for cardiovascular disease. Orally administered chitosan binds lipids in the small intestine and reduces their absorption. Chitosan has been shown to decrease serum cholesterol in animal and human studies. This study investigated the effectiveness of chitosan in reducing serum cholesterol without concomitant diet therapy. Methods: Ninety female volunteers (age 34 to 70 years) with confirmed mild to moderate hypercholesterolemia were enrolled into the study. They were randomly assigned to receive chitosan (1.2 g per day) or placebo in a double-blind manner. Serum lipids, body weight and adverse events were assessed at baseline and after 28 and 56 days of treatment. Subjects maintained their usual diet and documented the type and gross amount of food consumed. Results: Eighty-four subjects (41 chitosan, 43 placebo) were included in the analysis. Chitosan significantly (F = 3.19, p = 0.04) reduced total cholesterol compared to placebo. Additionally, chitosan significantly reduced total and LDL cholesterol (F = 4.21, p = 0.02, and F = 3.46, p = 0.04, respectively) compared to placebo in subjects over 60 years of age. Adverse effects were few; no serious events were reported. Conclusion: Our results demonstrate that chitosan is safe and effective for lowering cholesterol in subjects with hypercholesterolemia.