How Horse Chestnut interacts with Antiplatelet medications

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Studies have reported that horse chestnut affects the blood's clotting ability and may alter the effects of these medications and possibly the dose needed for treatment. Use with caution. (1) (2)

These drugs include aspirin, dipyridamole, anagrelide, cilostazol, clopidogrel, ticlopidine, abciximab, tirofiban, eptifibatide


  1. Dworschak E, et al. Medical Activities of Aesculus Hippocastaneum (Horse-chestnut) Saponins. Adv Exp Med Biol. 1996;404:471-74.
  2. View Abstract: Akopov SE, et al. Mechanisms of Platelet-induced Angiospastic Reactions: Potentiation of Calcium Sensitivity. Can J Physiol Pharmacol. Jul1997;75(7):849-52.