How Magnesium interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Study Supported

These antibiotics have been reported to bind with magnesium, which may decrease the absorption of both the drug and magnesium. Supplementation with the affected nutrient and adjustment in the drug dosage may be necessary. (1)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. View Abstract: Berthon G, et al. Metal Ion-tetracycline Interactions in Biological Fluids. 2. Potentiometric Study of Magnesium Complexes with Tetracycline, Oxytetracycline, Doxycycline, and Minocycline, and Discussion of Their Possible Influence on the Bioavailability of These Antibiotics in Blood Plasma. J Inorg Biochem. Aug1983;19(1):1-18.