How Calcium interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Proven

Tetracycline antibiotics bind to calcium in the stomach which prevents its absorption into the body. Check with your healthcare professional to determine if supplementation with this nutrient is necessary. (1)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. View Abstract: Lambs L, et al. Metal Ion-tetracycline Interactions in Biological Fluids. Part 3. Formation of Mixed-metal Ternary Complexes of Tetracycline, Oxytetracycline, Doxycycline and Minocycline with Calcium and Magnesium, and Their Involvement in the Bioavailability of These Antibiotics in Blood Plasma. Agents Actions. Jun1984;14(5-6):743-50.