How Melatonin interacts with Benzodiazepines

Interaction type: Depletions

Interaction rating: Study Supported

These medications may block a step in the formation of melatonin. Supplementation with the affected nutrient may be necessary. (1) (2) (3)

These drugs include alprazolam, diazepam, lorazepam, clorazepate dipotassium, chlordiazepoxide, oxazepam, buspirone, doxepin, hydroxyzine, meprobamate


  1. View Abstract: Wakabayashi H, et al. Effects of Diazepam Administration on Melatonin Synthesis in the Rat Pineal Gland in Vivo. Chem Pharm Bull.(Tokyo). Oct1991;39(10):2674-76.
  2. View Abstract: Monteleone P, et al. Preliminary Observations on the Suppression of Nocturnal Plasma Melatonin Levels by Short-term Administration of Diazepam in Humans. J Pineal Res. 1989;6(3): 253-58.
  3. View Abstract: McIntyre IM, Norman TR, Burrows GD, et al. Alterations to Plasma Melatonin and Cortisol After Evening Alprazolam Administration in Humans. Chronobiol Int. Jun1993;10(3):205-13.