How Vitamin B12 interacts with phenytoin

Interaction type: Depletions

Interaction rating: Study Supported

Phenytoin may decrease the absorption of vitamin B12 into certain cells in the body. Supplementation with the affected nutrient may be necessary. (1)


  1. View Abstract: Latham J, et al. Effects of Phenytoin Sodium On Doubling Time, Deoxyuridine Suppression, 3H-Methotrexate Uptake and 57Co-cyanocobalamin Uptake in HL60 Cells. Clin Lab Haematol. 1990;12(1):67-75.