How Vitamin B12 interacts with Proton pump inhibitors

Interaction type: Depletions

Interaction rating: Study Supported

These medications reduces the amount of acid in the stomach, which may decrease the absorption of vitamin B12 from the digestive tract into the body. Supplementation with the affected nutrient may be necessary. (1)

These drugs include lansoprazole, omeprazole, rabeprazole, pantoprazole, esomeprazole


  1. View Abstract: Marcuard SP, et al. Omeprazole Therapy Causes Malabsorption of Cyanocobalamin. Ann Intern Med. Feb1994;120(3):211-15.