How Vitamin C interacts with Tetracyclines

Interaction type: Depletions

Interaction rating: Study Supported

These medications may decrease vitamin C levels in the blood. It is not known if this decrease is significant or not. Supplementation with the affected nutrient may be necessary. (1)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. Shah KV, Barbhaiya HC, Srinivasan V. Ascorbic Acid Levels in Blood During Tetracycline Administration. J Indian Med Assoc. Aug1968;51(3):127-9.