How Calcium interacts with Tetracyclines

Interaction type: Interactions

Interaction rating: Proven

Tetracycline antibiotics chelate with calcium, which prevents its absorption. Supplementation with the affected nutrient may be necessary. (1)

These drugs include tetracycline, demeclocycline, doxycycline, minocycline, oxytetracycline


  1. View Abstract: Lambs L, et al. Metal Ion-tetracycline Interactions in Biological Fluids. Part 3. Formation of Mixed-metal Ternary Complexes of Tetracycline, Oxytetracycline, Doxycycline and Minocycline with Calcium and Magnesium, and Their Involvement in the Bioavailability of These Antibiotics in Blood Plasma. Agents Actions. Jun1984;14(5-6):743-50.