How Arginine interacts with Potassium-sparing diuretics

Interaction type: Interactions

Interaction rating: Potential/Theoritical

Since intravenous arginine infusions can cause hyperkalemia, this procedure should be used with caution with individuals who are taking potassium-sparing diuretics. (1)

These drugs include amiloride, triamterene, spironolactone


  1. View Abstract: Massara F, Martelli S, Ghigo E, et al. Arginine-induced Hypophosphatemia and Hyperkaliemia in Man. Diabete Metab. Dec1979;5(4):297-300.