Articles

Vanadium

Introduction

In the late 1960s, vanadium was found to be an essential trace mineral for plant nutrition, and in the early 1970s, it was discovered to be an essential nutrient for animals. There is still some debate on whether vanadium is essential in humans. Nonetheless, interest in vanadium as a nutritional substance has been steadily building over the past twenty years, especially since it was discovered that it can improve symptoms of diabetes.

Fats and vegetable oils are the richest food sources of vanadium. Vanadium also occurs in grains, meats, fish, and nuts. Dill seeds, parsley, black pepper, and mushrooms may also contain vanadium.

Dosage Info

Dosage Range

10-1,000mcg of elemental vanadium daily. Clinical studies evaluating the benefit of vanadium salts in type 2 diabetes mellitus use considerable higher doses: vanadyl sulfate 100mg to 300mg per day (1) , (2) , (3) or sodium metavanadate 125mg per day. (4)

Most Common Dosage

500mcg daily.

Dosage Forms

Tablets, capsules, and liquid.

Reported Uses

The most significant research on vanadium to date involves its insulin-like properties and its possible role in treating diabetes. Some studies have suggested that vanadium compounds help to normalize blood glucose levels in people with both type I and type II diabetes. (5)

Vanadium may also be a building material for the development of bones and teeth and it may be able to assist in lowering cholesterol levels.

Toxicities & Precautions

Introduction

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General

This dietary supplement is considered safe when used in accordance with proper dosing guidelines.

Side Effects

Side effects are possible with any dietary supplement. This dietary supplement may cause mild stomach and intestinal upset. (6) , (7) Tell your doctor if these side effects become severe or do not go away.

Pregnancy / Breast Feeding

To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Proper nutrition is essential during pregnancy for the healthy development of the fetus. Numerous vitamins and minerals are a vital part of proper nutrition. If you are pregnant, think you might be pregnant, trying to get pregnant, or breast-feeding an infant, talk to your healthcare professional about supplementing your diet with appropriate vitamins and minerals.

Age Limitations

To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Vitamins and minerals are an essential part of proper growth and development. Talk to your healthcare professional about the appropriate use of vitamins and minerals in children. Do not use any vitamin or mineral in children under 2 years of age unless first discussed with your healthcare professional.

References

  1. View Abstract: Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab. Mar2001;86(3):1410-1417.
  2. View Abstract: Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem. Dec1995;153(1-2):217-231.
  3. View Abstract: Boden F, et al. Effects of Vanadyl Sulfate on Carbohydrate and Lipid Metabolism in Patients with Non-insulin-dependent Diabetes Mellitus. Metabolism. Sep1996;45(9):1130-35.
  4. View Abstract: Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, et al. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. Mar2000;49(3):400-410.
  5. View Abstract: Ganguli S, et al. Effects of Maternal Vanadate Treatment of Fetal Development. Life Sci. 1994;55(16):1267-76.
  6. View Abstract: Boden F, et al. Effects of Vanadyl Sulfate on Carbohydrate and Lipid Metabolism in Patients with Non-insulin-dependent Diabetes Mellitus. Metabolism. Sep1996;45(9):1130-35.
  7. View Abstract: Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, et al. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. Mar2000;49(3):400-410.