Dong Gua Zi

Semen Benincasae, Waxgourd Seed


For oral usage, it is decocted and 10-15g is applied.

Chemical Composition

Oleic acid; Linoleic acid; Stearic acid; Palmitic acid; Octadecadienoic acid; Octadecatrienoic acid; Phosphatidyl choline; Phosphatidylinositol; Phosphatidylserine; Sphingomyelin; Cerebroside; b-sitosterol; Campesterol; Stigmasterol; Triterpenoids; Glutinol; Simiarenol; Phosphatidyl ethanolamine. (1)

Inorganic Chemicals

It also contains inorganic compounds such as, Se and Cr.


Patients of deficiency cold in the spleen and stomach should use with caution.


Enhancing immunity

Among the active components of Dong Gua Zi are substances containing large molecular compounds such as neutral sugar and aldonic acid, which have the activities of promoting mitosis, and of activating PBA and adjuvant activity. It is inferred that the active components of Dong Gua Zi take part in the non-specific defense function of the host body. (2)

Inhibiting trypsin

Research has isolated Dong Gua Zi components that have an inhibitory effect on trypsin. Two of the four components are small molecular trypsin-inhibitors. (3)


  1. Editorial Committee of Chinese Materia Medica. State Drug Administration of China. Chinese Materia Medica. Shanghai: Science and Technology Press; 1998.
  2. Xiong Ze Yi Xiong, et al. Immune-enhancing components of Dong Gua Zi: their separation and biological activities. Foreign Medicine (TCM vol). 1984;(2):50.
  3. Chen Yan. The purification and certain characteristics of Dong Gua Zi’s small molecular trypsin-inhibitors. Journal of Molecular Biology and Biological Physics. 1986;18(6):485-490.