Garcinia in gastric ulcers.




Phytother Res

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Consumer Data: Garcinia
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Gastric and duodenal ulcers both present with symptoms of pain, often described as annoying, burning, gnawing, and aching. Duodenal ulcer pain usually occurs when the stomach is empty, such as during the night or between meals, and is relieved by food. The symptoms can last for weeks, followed by a period with no symptoms. With gastric ulcers, the pain occurs at any time during the day, but frequently occurs immediately or within a couple of hours of eating a meal. However, pain does not always mean the presence of an ulcer. Other less common symptoms associated with the development of an ulcer include nausea, vomiting, belching, bloating, and anorexia. Bleeding can also occur; prolonged bleeding may cause anemia leading to weakness and fatigue. Patients displaying no symptoms have also been diagnosed with an ulcer. 25 million Americans will suffer from an ulcer at some point during their lifetime.1

A recent investigation looked into the possible outcomes of using the herb garcinia in treating and preventing gastric ulcers. The use of this herb has been rapidly growing in the United States due to its popularity as a weight loss aid. As part of a lifestyle that includes good nutrition and exercise, garcinia may favorably modify metabolism and appetite. These benefits could help people lose weight and lead healthier, more active lives.

This study published in Phytotherapy Research used 1 gram of garcinia fruit extract per kg of body weight in rats. This extract was used as a pretreatment for 5, 10, and 15 days. The pretreatment of the garcinia resulted in protection of the ulcerogenic induced chemical indomethacin. In addition, in the rats that were untreated with the extract, the glycoprotein levels were decreased while those in the garcinia group maintained normal levels. In the treated rats, the amount and acidity of gastric juice decreased. The authors concluded that, "Garcinia cambogia was able to decrease the acidity and to increase the mucosal defense in the gastric areas, thereby justifying its use as an antiulcerogenic agent."2


1. The Center for Disease Control, 2001.
2.Mahendran P. The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats. Phytother Res. Feb 2002;16(1):80.