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Murraya paniculata

Synonyms

Chalcas paniculata, Chalcas cammueng, Murraea exotica, Marsana buxifolia, Chalcas japonensis, Murraya amoena, Murraya sumatrana, Chalcas intermedia, Chalcas sumatrana, Murraya glenieii, Murraya brevifolia, Murraya scandens, Camunium exoticum [1]

Vernacular Names:

Malaysia Kemuning
English Chinese myrtle, Chinese box-wood, Burmese box-wood, Orange Jasmine
Indonesia Kemoening, Djenar
Thailand Keo
Philippines Banaasi, Kamuning
China Jui-li-xiang, Kau lei heung, Guo mai Shuang gao la
Hong Kong Gou-lee-heung
India Kamini marchula, Pandari, Nagagolunga, Konji, Angarakana gida, Ban mallika
Nepal Bajardante
French Buis de Chine [1]

General Information

Description

Murraya paniculata is a member of the Rutaceae family. It is an evergreen shrub with grey corky bark. The leaves are stalked, three to nine-foliolate; leaflets have short petioles and measures between 2.5-7.5 cm x 1.5-2.5 cm, obliquely rhombic, more or less acuminate, entire, leathery when mature, shiny above. The flowers are white in colour, fragrant, in axillary or terminal corymbs. The fruits are berries, narrowed at both ends, bright red and dark red when rip. It contains two seeds.[8]

Plant Part Used

Leaves, bark and roots [2]

Chemical Constituents

2'-O-ethylmurrangatin;   hainanmurpanin;  murralonginal; murranganone; murrmeranzin;  minumicrolin; murrangatin; meranzin hydrate;  omphamurrayin;  paniculatin;  yuehchukene [2] [3]

Traditional Used:

In Nepal the leaves are chewed for toothaches.[8] In Malaysia the decoction of the leaves can be used as a gargle to treat toothache.[9]

The leaves are frequently used to treat pain due to scalding. This decoction can be given orally to treat body aches, as a tonic, and for expelling tape worm.[9]

Pre-Clinical Data

Pharmacology


Oestrogenic activity
 
Yuehchukene is an alkaloid isolated from roots of M. paniculata has oestrogenic activity as evidenced by 100% anti-implantation effects on 1 – 3 day gestation in female mice. When given to immature female mice there was an increase in the weight of the uterus. However, the oestrogenic activity was weaker than estradiol.[2]

Anticholinesterase activity

Two compounds, murranganone and paniculatin, isolated from the leaves of M. paniculata was found to have cholinesterase inhibitory activity. Another compound, minumicrolin isolated from the aerial parts of Murraya paniculata has mild butyryl-cholinesterase inhibitory activity.[4] [6]

Antiprotozoal activity

The chloroform exctract from M. paniculata was found to be moderately active against Giardia intestinalis infestation. The extract also showed moderate activity agains Entamoeba histolytica.[5] [6]

Toxicities

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effects in Human:

No documentation

Used in Certain Conditions

Pregnancy / Breastfeeding

The use of this plant during pregnancy is not advisable as it may interfere with implantations processes. On the other hand if contraception is need then it has the potential of acting an oral contraceptive medicine.

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contraindications

Contraindications

No documentation

Case Reports

No documentation

References

    1. Peter Hanelt Mansfeld’s Encyclopedia of Agricultural and Horticultural Crops Volume 5 Springer-Verlag Berlin 2001 pg. 1012 – 1013
    2. Wang NG, Guan MZ, Lei HP. [Studies on anti-implantation and hormone activity of yuehchukene, an alkaloid isolated from the root of Murraya paniculata] Yao Xue Xue Bao. 1990;25(2):85-9.
    3. Kinoshita T, Shimada M. Isolation and structure elucidation of a new prenylcoumarin from Murraya paniculata var. omphalocarpa (Rutaceae). Chem Pharm Bull (Tokyo). 2002 Jan;50(1):118-20.
    4. Choudhary MI, Azizuddin, Khalid A, Sultani SZ, Atta-ur-Rahman. A new coumarin from Murraya paniculata. Planta Med. 2002 Jan;68(1):81-3.
    5. Sawangjaroen N, Subhadhirasakul S, Phongpaichit S, Siripanth C, Jamjaroen K, Sawangjaroen K. The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand. Parasitol Res. 2005 Jan;95(1):17-21. Epub 2004 Nov 18.
    6. Sawangjaroen N, Phongpaichit S, Subhadhirasakul S, Visutthi M, Srisuwan N, Thammapalerd N. The anti-amoebic activity of some medicinal plants used by AIDS patients in southern Thailand. Parasitol Res. 2006 May;98(6):588-92. Epub 2006 Jan 31.
    7. Saied S, Nizami SS, Anis I. Two new coumarins from Murraya paniculata. J Asian Nat Prod Res. 2008 May-Jun;10(5-6):515-9.
    8. N.P. Manandhar, Sanjay Manandhar Plants and People of Nepals Timber Press  Inc. Portland 2002 pg. 326
    9. Kamaruddin Mat-Salleh, A. Latiff Tumbuhan Ubatan Malaysia Pusat Pengurusan Penyelidikan Universiti Kebanhgsaan Malaysia Bangi 2002 pg. 47

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