| PERIOD | MAJOR MILESTONE |
| 3000 BC | Tirumantiram written by Tirumular deals elaborately with Mind – Body relationship, Embryology (Karuvurpatti), Five element theory, Attanka Yokam and Atomic theory. |
| 1400 BC | Tolkappiyam, the earliest extant Tamil grammar book deals with the concept of five basic elements (Aimputam). |
| 600 BC | Acivakam – Philosophy and basics of Tamil medicine. |
| 600 BC | Jain literature – Philosophy of Siddha medicine. |
| 200BC | Tirukkal – A chapter on medicine — Maruntu Atikaram. |
| AD 200 | Manimekalai — Theory of Logic (Alavai). |
| AD 100-500 | Elati, Tirikatukam have been named after Siddha drugs. |
| AD 700 | Tiruvacakam, an ancient Tamil literature contains details of Caiva Cittanta philosophy which forms an integral part of Siddha fundamental concepts. |
| AD 1121 | Princess Kuntavai Nacciyar established a free dispensary in the name of her father Cuntarac Cozan. |
| AD 1200 | Periyapuranam contains description of certain diseases. |
| AD 1700 | Mannar Carapoji of Tacavur took interest in the preservation and propagation of indigenous systems of medicine. He was instrumental in the compilation of ‘Carapentira Vaittiya Muraikal’ and researches were done in Indian systems like Siddha, Ayurveda and Unani. |
| AD 1925 | Government School of Indian Medicine was established in Madras to teach Siddha, Ayurveda and Unani (institutionalising of Siddha medical education). |
| AD 1975 | The Siddha Pharmacopoeia Committee (SPC) was constituted. |
| AD 1985 | Starting of the second Siddha Medical College for B.S.M.S Degree Course by Government of Tamil Nadu at Pazani (affiliated to Madurai Kamaraj University) and it was later shifted to Chennai in 1993. |
| AD 1995 | A separate department of Indian Systems of Medicine and Homoeopathy was created by Government of India under the Ministry of Health & Family Welfare. The department was renamed as Department of AYUSH in 2003. |
| AD 2017 | Through Indian Technical and Economic Cooperation (ITEC) programme, a Siddha (Varmam) Unit started functioning since 2017 in Sungai Buloh Hospital near Kuala Lumpur, Malaysia. |
